Meg even stated she loved her in "Peter's Daughter", only for Lois to not even respond.
Peter seems to unintentionally do his absolute best to be a thorn in her side.
Lois is currently a full-time-mom and spends most of the working day caring for Stewie, cleaning the house and cooking food for her family.
She also has occasionally laughed at Brian such as when she and Peter laughed at Brian when he unknowingly had sex with Quagmire's father and did not bother to tell him why they were laughing at him. She is reportedly two years younger than Peter as claimed in "Let's Go to the absolutely no emotion or interest and in other cases draw pleasure from others misery.